Designing new tools for synthetic biology in mammalian cells
Velia Siciliano (Imperial College London)
Synthetic Biology aims at developing and applying engineering tools to sense and process endogenous information and to implement robust responses to intracellular conditions. Mammalian synthetic networks build on the conjugation of efforts to increase the number of DNA parts for genetic circuit assembly with minimal counteractive effect with the intracellular context, with the ability to design circuits that are activated when specific endogenous molecules are sensed within the cells. I will show our results on designing new genetic parts such as transcriptional activators and repressor in mammalian cells, and circuits based on RNA binding proteins as a new potential platform of gene delivery and genetic circuits regulation.
Time: 12noon, Thursday 23rd November
Venue: Swann Building Seminar room 7.20, Kings Buildings
Host: Filippo Menolascina