Innovating research, policy and education in synthetic and systems biology

Microscopy Facility

To design successful synthetic gene circuits, we need to understand how engineered systems interact with their host cells. We complement modelling approaches by collecting data on cell growth and behaviour in our timelapse microscopy facility, which allows us to measure physiological variables in thousands of individual yeast cells throughout their lifetime.

Microfluidic devices, manufactured in collaboration with the Scottish Microelectronics Centre, are used to trap cells for observation in controlled conditions (Crane et al. 2014 )

  • We have three automated wide field microscopes adapted for use in long term time lapse experiments
  • Custom-written software controls image acquisition in coordination with media flow to microfluidic devices
  • Cells are detected in recorded images using a machine-learning approach in custom image analysis software

For further information please contact Dr Ivan Clark Microscopy Manager