To design successful synthetic gene circuits, we need to understand how engineered systems interact with their host cells. We complement modelling approaches by collecting data on cell growth and behaviour in our timelapse microscopy facility, which allows us to measure physiological variables in thousands of individual yeast cells throughout their lifetime.
- We have three automated wide field microscopes adapted for use in long term time lapse experiments
- Custom-written software controls image acquisition in coordination with media flow to microfluidic devices
- Cells are detected in recorded images using a machine-learning approach in custom image analysis software
For further information please contact Dr Ivan Clark Microscopy Manager