Systems biology in SynthSys has a wide remit, with research ranging from microbes to plants to mammalian cells. We were one of six centres for integrative systems biology founded by the UK government in 2006-2007 and have now a well-established track record in innovative interdisciplinary research.
Systems biology aims to understand how genes and proteins interact and endow cells with the characteristics associated with life, such as the abilities to sense, move, grow and divide. A focus is to study biochemistry in terms of its relevance to the goals of the organism being studied. We are interested in why genetic and protein networks have the structure they do, and, as such, our work underpins that in synthetic biology.
In particular we specialize in:
- Single-cell assays: light and fluorescence microscopy and the novel use of microfluidics for quantitative phenotyping and for generating fluctuating extracellular environments
- Multi-scale and rule-based mathematical modeling: from genetic networks to predictions of growth rates in microbes or flowering times in plants
- Stochastic gene expression: mathematical modeling, statistical inference, and single-cell measurements
- Spatial mathematical modeling: pattern formation, macromolecular crowding, stochastic simulation algorithms for diffusion, and the analysis of high-resolution capture (Hi-C) data
- Anti-microbial resistance: the response of bacteria to different temporal and spatial regimens of antibiotics
- Infection: the interaction between the human immune system and metabolism during infection, particularly early in life
- Plant systems biology: signalling networks that sense light and temperature, circadian rhythms, and biomechanics
We have close links with the MRC Centre for Regenerative Medicine, the Scottish Microelectronics Centre, and the Kinetic Parameter Facility.